Dynamic Human Brain Imaging with a Portable PET Camera: Comparison to a Standard Scanner.
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- Record sourced from PubMed, PMID 38124218.
- Also identified by DOI 10.2967/jnumed.122.265309 and PMC identifier 10858383.
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Abstract
Portable, cost-effective PET cameras can radically expand the applicability of PET. We present here a within-participant comparison of fully quantified [<sup>18</sup>F]FDG dynamic scans in healthy volunteers using the standard Biograph mCT scanner and portable CerePET scanner. <b>Methods:</b> Each of 20 healthy volunteers underwent dynamic [<sup>18</sup>F]FDG imaging with both scanners (1-154 d apart) and concurrent arterial blood sampling. Tracer SUV, net influx rate (K<sub>i</sub>), and the corresponding cerebral metabolic rate of glucose (CMR<sub>glu</sub>) were quantified at regional and voxel levels. <b>Results:</b> At the regional level, CerePET outcome measure estimates within participants robustly correlated with Biograph mCT estimates in the neocortex, wherein the average Pearson correlation coefficients across participants ± SD were 0.83 ± 0.07 (SUV) and 0.85 ± 0.08 (K<sub>i</sub> and CMR<sub>glu</sub>). There was also strong agreement between CerePET and Biograph mCT estimates, wherein the average regression slopes across participants were 0.84 ± 0.17 (SUV), 0.83 ± 0.17 (K<sub>i</sub>), and 0.85 ± 0.18 (CMR<sub>glu</sub>). There was similar bias across participants but higher correlation and less variability in subcortical regions than in cortical regions. Pearson correlation coefficients for subcortical regions equaled 0.97 ± 0.02 (SUV) and 0.97 ± 0.03 (K<sub>i</sub> and CMR<sub>glu</sub>), and average regression slopes equaled 0.79 ± 0.14 (SUV), 0.83 ± 0.11 (K<sub>i</sub>), and 0.86 ± 0.11 (CMR<sub>glu</sub>). In voxelwise assessment, CerePET and Biograph mCT estimates across outcome measures were significantly different only in a cluster of left frontal white matter. <b>Conclusion:</b> Our results indicate robust correlation and agreement between semi- and fully quantitative brain glucose metabolism measurements from portable CerePET and standard Biograph mCT scanners. The results obtained with a portable PET scanner in this comparison in humans require follow-up but lend confidence to the feasibility of more flexible and portable brain imaging with PET.
Medical subject headings
- Fluorodeoxyglucose F18
- Neocortex