SOHPIE: statistical approach via pseudo-value information and estimation for differential network analysis of microbiome data.
Where this comes from
- Record sourced from PubMed, PMID 38134422.
- Also identified by DOI 10.1093/bioinformatics/btad766 and PMC identifier 10807904.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The SOHPIE R package implements a novel functionality for "multivariable" differential co-abundance network (DN, hereafter) analyses of microbiome data. It incorporates a regression approach that adjusts for additional covariates for DN analyses. This distinguishes from previous prominent approaches in DN analyses such as MDiNE and NetCoMi which do not feature a covariate adjustment of finding taxa that are differentially connected (DC, hereafter) between individuals with different clinical and phenotypic characteristics. SOHPIE with a vignette is available on CRAN repository https://CRAN.R-project.org/package=SOHPIE and published under General Public License (GPL) version 3 license.
Medical subject headings
- Software
- Microbiota