Levetiracetam: A Potent Sword against Microglia Polarization in Gliomas.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 38170191.
- Also identified by DOI 10.1158/1078-0432.CCR-23-3322.
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Abstract
Crosstalk between tumor cells and peritumoral cells contributes to immunosuppressive microenvironment formation in glioblastomas (GBM). A recent study revealed that glioma stem cells activated neuronal activity to promote microglial M2 polarization, leading to GBM progression, which could be pharmacologically blocked by levetiracetam, providing a practical strategy for GBM immunotherapy. See related article by Guo et al., p. 1160.
Medical subject headings
- Glioma
- Glioblastoma
- Brain Neoplasms