Tumor-associated Macrophages in Merkel Cell Carcinoma: Old Balances, New Checks.
review · Level V
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- Record sourced from PubMed, PMID 38170200.
- Also identified by DOI 10.1158/1078-0432.CCR-23-3320.
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Abstract
A recent report sheds light on the tumor-associated macrophages (TAMs) in MCC, and the association of S100A8-expressing TAMs with resistance to anti-PD-(L)1 inhibitors. These data improve our understanding about why some tumors with brisk TIL do not respond to immunotherapy and provide a compelling rationale to target myeloid checkpoints in MCC.