TAMC-derived creatine sustains glioblastoma growth.
Level V
Where this comes from
- Record sourced from PubMed, PMID 38171329.
- Also identified by DOI 10.1016/j.cmet.2023.12.012.
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Abstract
Tumor-associated myeloid cells (TAMCs) are the predominant immune population in glioblastoma (GBM), but the definite role of TAMCs in GBM tumorigenicity remains uncertain. In this issue of Cell Metabolism, Rashidi et al. identify a specific population of TAMCs surrounding hypoxic regions of GBM. These TAMCs provide creatine to nearby tumor cells to promote GBM progression.
Medical subject headings
- Glioblastoma
- Brain Neoplasms