H<sub>2</sub>S serves as the immunoregulatory essence of apoptotic cell death.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38171337.
- Also identified by DOI 10.1016/j.cmet.2023.12.006 and PMC identifier 11750157.
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Abstract
Apoptosis supports tissue homeostasis and prevents immune disorders by removing damaged and functionally aberrant cells. Here, Ou et al. utilized genetic, pharmacological, and proteomic approaches focused on sulfur amino acid catabolism to discover that hydrogen sulfide (H<sub>2</sub>S) release during apoptosis suppresses Th17 cell differentiation, thus providing therapeutic targets for autoimmune diseases.
Medical subject headings
- Proteomics
- Hydrogen Sulfide