Hallmarks of stemness in mammalian tissues.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 38181752.
- Also identified by DOI 10.1016/j.stem.2023.12.006 and PMC identifier 10769195.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
All adult tissues experience wear and tear. Most tissues can compensate for cell loss through the activity of resident stem cells. Although the cellular maintenance strategies vary greatly between different adult (read: postnatal) tissues, the function of stem cells is best defined by their capacity to replace lost tissue through division. We discuss a set of six complementary hallmarks that are key enabling features of this basic function. These include longevity and self-renewal, multipotency, transplantability, plasticity, dependence on niche signals, and maintenance of genome integrity. We discuss these hallmarks in the context of some of the best-understood adult stem cell niches.
Medical subject headings
- Mammals
- Stem Cell Niche