Regulators of necroinflammation in acute kidney injury.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 38182296.
- Also identified by DOI 10.1016/j.kint.2023.10.019.
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Abstract
Interleukin (IL)-22 is unique among the ILs as it elicits direct effects on kidney epithelia and regulates cell survival in a context-dependent manner. Studies published in Kidney International and other journals demonstrate opposing roles of IL-22 (e.g., in models of acute kidney injury). In the early necroinflammation phase of acute kidney injury, IL-22 promotes tubular cell death, whereas it enhances the proliferation and regeneration of epithelial barrier function in the healing phase of injured tubules.
Medical subject headings
- Acute Kidney Injury