Delivery of a sebum modulator by an engineered skin microbe in mice.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38195987.
- Also identified by DOI 10.1038/s41587-023-02072-4.
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Abstract
Microorganisms can be equipped with synthetic genetic programs for the production of targeted therapeutic molecules. Cutibacterium acnes is the most abundant commensal of the human skin, making it an attractive chassis to create skin-delivered therapeutics. Here, we report the engineering of this bacterium to produce and secrete the therapeutic molecule neutrophil gelatinase-associated lipocalin, in vivo, for the modulation of cutaneous sebum production.
Medical subject headings
- Sebum
- Skin