A New Twist on a Classic: Enhancing Radioiodine Uptake in Advanced Thyroid Cancer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38197869.
- Also identified by DOI 10.1158/1078-0432.CCR-23-3503 and PMC identifier 10984766.
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Abstract
Advanced differentiated thyroid cancer that is resistant to radioactive iodine therapy may become responsive with a unique treatment combination of chloroquine and vorinostat. This treatment was demonstrated in cellular and animal models of thyroid cancer to inhibit endocytosis of the plasma membrane-bound iodine transporter, NIS, and restore iodine uptake. See related article by Read et al., p. 1352.
Medical subject headings
- Thyroid Neoplasms
- Symporters
- Iodine