Implications of stress-induced gene expression for hematopoietic stem cell aging studies.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38228925.
- Also identified by DOI 10.1038/s43587-023-00558-z and PMC identifier 10878961.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
A decline in hematopoietic stem cell (HSC) function is believed to underlie hematological shortcomings with age; however, a comprehensive molecular understanding of these changes is currently lacking. Here we provide evidence that a transcriptional signature reported in several previous studies on HSC aging is linked to stress-induced changes in gene expression rather than aging. Our findings have strong implications for the design and interpretation of HSC aging studies.
Medical subject headings
- Hematopoietic Stem Cells