Hunting for the vulnerability in chondrosarcoma by tracing metabolic and genetic links.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38232691.
- Also identified by DOI 10.1016/j.xcrm.2023.101385 and PMC identifier 10829863.
- Licence recorded as CC BY-NC-ND.
- Because redistribution is not established, this page shows the abstract only. Follow the links below for the full text.
Abstract
In this Backstory, we narrate our journey in establishing a multidisciplinary team for sarcoma research and uncovering vulnerabilities in chondrosarcoma cells associated with their NAD<sup>+</sup> dependencies for survival.<sup>1</sup> Our findings hold promise for exploitation, yielding a synergistic cytotoxic effect when combined with systemic therapy.
Medical subject headings
- Antineoplastic Agents
- Bone Neoplasms
- Chondrosarcoma