A four-cell pathway orchestrated by Flt3-L-dependent cDCs controls anti-tumor responses.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38232704.
- Also identified by DOI 10.1016/j.xcrm.2023.101378 and PMC identifier 10829860.
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Abstract
A study by Régnier et al. shows that Flt3-ligand (FL) levels program two distinct mechanisms of anti-tumor immunity. Low FL levels allow recruitment of T effectors and T cell-mediated responses whereas high FL levels support recruitment of classical dendritic cells (cDC) and natural killer (NK) cells and NK-mediated anti-tumor responses.
Medical subject headings
- Killer Cells, Natural
- Neoplasms