Somatic POLE Mutation and Ultra-Hypermutated Genotype in a De Novo High-Grade, Isocitrate Dehydrogenase Wild-Type Glioma: Treatment Implications.

Mundt, Daniel; Melguizo-Gavilanes, Isaac; Tumu, Anil Y; Dubner, Steven; Walters, Mary K; McFarlane, Laura · JCO Precis Oncol · 2024

case_report · Level V

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Abstract

Pembrolizumab leads to a durable response in ultra-hypermutated, high-grade, glioma.

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