Photo-responsive hydrogels based on a ruthenium complex: synthesis and degradation.
basic_science · Level V
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- Record sourced from PubMed, PMID 38240363.
- Also identified by DOI 10.1039/d3sm01232h.
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Abstract
We report the synthesis of a photo responsive metallo-hydrogel based on a ruthenium(II) complex as a functional cross-linker. This metal complex contains reactive 4AAMP (= 4-(acrylamidomethyl)pyridine) ligands, which can be cleaved by light-induced ligand substitution. Ru[(bpy)<sub>2</sub>(4AAMP)<sub>2</sub>] cross-links 4-arm-PEG-SH macromonomers by thia-Michael-addition to the photocleavable 4AAMP ligand for the preparation of the hydrogel. Irradiation with green light at 529 nm leads to photodegradation of the metallo-hydrogel due to the ligand dissociation, which can be adjusted by adjusting the Ru[(bpy)<sub>2</sub>(4AAMP)<sub>2</sub>] concentration. The ligand substitution forming [Ru(bpy)<sub>2</sub>(L)<sub>2</sub>]<sup>2+</sup> (L = H<sub>2</sub>O and CH<sub>3</sub>CN) can be monitored by <sup>1</sup>H NMR spectroscopy and UV-visible absorption. The control of degradation by light irradiation plays a significant role in modulating the elasticity and stiffness of the light sensitive metallo-hydrogel network. The photo-responsive hydrogel is a viable substrate for cell cultures.