Multi-omics data integration shines a light on the renal medulla.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38245213.
- Also identified by DOI 10.1016/j.kint.2023.11.014.
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Abstract
The renal medulla maintains salt and water balance and is prone to dysregulation because of high oxygen demand. Challenges in obtaining high-quality tissue have limited characterization of molecular programs regulating the medulla. Haug et al. leveraged gene expression, chromatin accessibility, long-range chromosomal interactions, and spatial transcriptomics to build a reference set of medullary tissue marker genes to define the medullary role in kidney function, exemplifying the strength and utility of multi-omic data integration.
Medical subject headings
- Multiomics
- Kidney Medulla