Immunology: Meta-learning for T cell-receptor binding specificity and beyond.

Wang, Duolin; He, Fei; Yu, Yang; Xu, Dong · Nat Mach Intell · 2023

basic_science · Level V

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Abstract

Predicting whether T-cell receptors bind to specific peptides is a challenging problem as the majority of binding examples in the training data involves only a few peptides. A new approach employs meta-learning to improve predictions for binding to peptides for which no or little binding data exists.