Compartmentalized SARS-CoV-2 Replication in the Upper vs Lower Respiratory Tract After Intranasal Inoculation or Aerosol Exposure.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38261786.
- Also identified by DOI 10.1093/infdis/jiae018 and PMC identifier 11420804.
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Abstract
Nonhuman primate models are essential for the development of vaccines and antivirals against infectious diseases. Rhesus macaques are a widely utilized infection model for SARS-CoV-2. We compared cellular tropism and virus replication in rhesus macaques inoculated with SARS-CoV-2 via the intranasal route or via exposure to aerosols. Intranasal inoculation resulted in replication in the upper respiratory tract with limited involvement in the lower respiratory tract, whereas exposure to aerosols resulted in infection throughout the respiratory tract. In comparison with multiroute inoculation, intranasal and aerosol inoculation resulted in reduced SARS-CoV-2 replication in the respiratory tract.
Medical subject headings
- Macaca mulatta
- SARS-CoV-2
- Virus Replication
- Administration, Intranasal
- COVID-19
- Aerosols
- Disease Models, Animal