T cell lymphoma and secondary primary malignancy risk after commercial CAR T cell therapy.

Ghilardi, Guido; Fraietta, Joseph A; Gerson, James N; Van Deerlin, Vivianna M; Morrissette, Jennifer J D; Caponetti, Gabriel C; Paruzzo, Luca; Harris, Jaryse C et al. · Nat Med · 2024

retrospective_cohort · Level III

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Abstract

We report a T cell lymphoma (TCL) occurring 3 months after anti-CD19 chimeric antigen receptor (CAR) T cell immunotherapy for non-Hodgkin B cell lymphoma. The TCL was diagnosed from a thoracic lymph node upon surgery for lung cancer. The TCL exhibited CD8<sup>+</sup> cytotoxic phenotype and a JAK3 variant, while the CAR transgene was very low. The T cell clone was identified at low levels in the blood before CAR T infusion and in lung cancer. To assess the overall risk of secondary primary malignancy after commercial CAR T (CD19, BCMA), we analyzed 449 patients treated at the University of Pennsylvania. At a median follow-up of 10.3 months, 16 patients (3.6%) had a secondary primary malignancy. The median onset time was 26.4 and 9.7 months for solid and hematological malignancies, respectively. The projected 5-year cumulative incidence is 15.2% for solid and 2.3% for hematological malignancies. Overall, one case of TCL was observed, suggesting a low risk of TCL after CAR T.

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