Precision Medicine in Parkinson's Disease Using Induced Pluripotent Stem Cells.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38269602.
- Also identified by DOI 10.1002/adhm.202303041.
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Abstract
Parkinson's disease (PD) is one of the most devastating neurological diseases; however, there is no effective cure yet. The availability of human induced pluripotent stem cells (iPSCs) provides unprecedented opportunities to understand the pathogenic mechanism and identification of new therapy for PD. Here a new model system of PD, including 2D human iPSC-derived midbrain dopaminergic (mDA) neurons, 3D iPSC-derived midbrain organoids (MOs) with cellular complexity, and more advanced microphysiological systems (MPS) with 3D organoids, is introduced. It is believed that successful integrations and applications of iPSC, organoid, and MPS technologies can bring new insight on PD's pathogenesis that will lead to more effective treatments for this debilitating disease.
Medical subject headings
- Induced Pluripotent Stem Cells
- Parkinson Disease
- Precision Medicine
- Organoids
- Dopaminergic Neurons