Kidins220 regulates the development of B cells bearing the λ light chain.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38271217.
- Also identified by DOI 10.7554/eLife.83943 and PMC identifier 10810608.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
The ratio between κ and λ light chain (LC)-expressing B cells varies considerably between species. We recently identified Kinase D-interacting substrate of 220 kDa (Kidins220) as an interaction partner of the BCR. <i>In vivo</i> ablation of Kidins220 in B cells resulted in a marked reduction of λLC-expressing B cells. Kidins220 knockout B cells fail to open and recombine the genes of the <i>Igl</i> locus, even in genetic scenarios where the <i>Igk</i> genes cannot be rearranged or where the κLC confers autoreactivity. <i>Igk</i> gene recombination and expression in Kidins220-deficient B cells is normal. Kidins220 regulates the development of λLC B cells by enhancing the survival of developing B cells and thereby extending the time-window in which the <i>Igl</i> locus opens and the genes are rearranged and transcribed. Further, our data suggest that Kidins220 guarantees optimal pre-BCR and BCR signaling to induce <i>Igl</i> locus opening and gene recombination during B cell development and receptor editing.
Medical subject headings
- B-Lymphocytes
- Signal Transduction