The Rise of Adaptive Platform Trials in Critical Care.

PRACTICAL, PANTHER, TRAITS, INCEPT, and REMAP-CAP investigators · Am J Respir Crit Care Med · 2024

review · Level V

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Abstract

As durable learning research systems, adaptive platform trials represent a transformative new approach to accelerating clinical evaluation and discovery in critical care. This Perspective provides a brief introduction to the concept of adaptive platform trials, describes several established and emerging platforms in critical care, and surveys some opportunities and challenges for their implementation and impact.

Medical subject headings