IL15 and IL21: Better When Membrane-Tethered Together on Antitumor T Cells.
editorial · Level V
Where this comes from
- Record sourced from PubMed, PMID 38289325.
- Also identified by DOI 10.1158/1078-0432.CCR-23-3466 and PMC identifier 12079554.
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Abstract
Systemic administration of homeostatic γ-chain cytokines mediates antitumor responses in some patients treated with adoptive immunotherapy. Yet many patients experience toxic side effects. New work presented herein suggests these limitations can be overcome by membrane-tethering IL15 and IL21 to T-cell products. This finding has major implications in advancing medicine. See related article by Nguyen et al., p. 1555.
Medical subject headings
- T-Lymphocytes
- Interleukin-15