Sequential Treatment Failure With Aztreonam-Ceftazidime-Avibactam Followed by Cefiderocol Due to Preexisting and Acquired Mechanisms in a New Delhi Metallo-β-lactamase-Producing Escherichia coli Causing Fatal Bloodstream Infection.
case_report · Level V
Where this comes from
- Record sourced from PubMed, PMID 38289725.
- Also identified by DOI 10.1093/cid/ciad759.
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Abstract
We report a fatal case of New Delhi metallo-β-lactamase (NDM)-producing Escherichia coli in a bacteremic patient with sequential failure of aztreonam plus ceftazidime-avibactam followed by cefiderocol. Acquired resistance was documented phenotypically and mediated through preexisting and acquired mutations. This case highlights the need to rethink optimal treatment for NDM-producing organisms.
Medical subject headings
- Azabicyclo Compounds
- beta-Lactamases
- Aztreonam
- Drug Combinations
- Ceftazidime
- Anti-Bacterial Agents
- Escherichia coli
- Escherichia coli Infections
- Cefiderocol
- Bacteremia
- Cephalosporins
- Treatment Failure