Degradation trumps mutations in cancer.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38301021.
- Also identified by DOI 10.1126/science.adn4945.
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Abstract
Redirecting targeted proteins for degradation can overcome acquired drug resistance.
Medical subject headings
- Drug Resistance, Neoplasm
- Protein Kinase Inhibitors
- Leukemia, Lymphocytic, Chronic, B-Cell
- Proteolysis