Structure is beauty, but not always truth.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 38306978.
- Also identified by DOI 10.1016/j.cell.2024.01.003 and PMC identifier 10947451.
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Abstract
Structural biology, as powerful as it is, can be misleading. We highlight four fundamental challenges: interpreting raw experimental data; accounting for motion; addressing the misleading nature of in vitro structures; and unraveling interactions between drugs and "anti-targets." Overcoming these challenges will amplify the impact of structural biology on drug discovery.
Medical subject headings
- Drug Discovery
- Molecular Biology