Metabolic regulation of the hallmarks of stem cell biology.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 38306993.
- Also identified by DOI 10.1016/j.stem.2024.01.003 and PMC identifier 10842269.
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Abstract
Stem cells perform many different functions, each of which requires specific metabolic adaptations. Over the past decades, studies of pluripotent and tissue stem cells have uncovered a range of metabolic preferences and strategies that correlate with or exert control over specific cell states. This review aims to describe the common themes that emerge from the study of stem cell metabolism: (1) metabolic pathways supporting stem cell proliferation, (2) metabolic pathways maintaining stem cell quiescence, (3) metabolic control of cellular stress responses and cell death, (4) metabolic regulation of stem cell identity, and (5) metabolic requirements of the stem cell niche.
Medical subject headings
- Stem Cells