Prebiotic access to enantioenriched amino acids via peptide-mediated transamination reactions.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38315856.
- Also identified by DOI 10.1073/pnas.2315447121 and PMC identifier 10873602.
- Licence recorded as CC BY-NC-ND.
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Abstract
The kinetic resolution of racemic amino acids mediated by dipeptides and pyridoxal provides a prebiotically plausible route to enantioenriched proteinogenic amino acids. The enzymatic transamination cycles that are key to modern biochemical formation of enantiopure amino acids may have evolved from this half of the reversible reaction couple. Kinetic resolution of racemic precursors emerges as a general route to enantioenrichment under prebiotic conditions.
Medical subject headings
- Amino Acids
- Peptides