Independent Oversight of Clinical Trials through Data and Safety Monitoring Boards.

Evans, Scott R · NEJM Evid · 2022

review · Level V

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Abstract

DSMBs: Protecting Patients and Scientific IntegrityDSMBs look after the welfare of patients enrolled in interventional clinical trials. DSMBs monitor for early establishment of efficacy, findings of harm, futility in obtaining a meaningful outcome, or changes in the ecology of care that render moot the question a trial aims to answer. This article opens a series of <i>NEJM Evidence</i> reviews about DSMBs.

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