Strategies to Account for Design Misspecifications in Randomized Controlled Trials.

Ruppert, Amy S; Mandrekar, Sumithra J · NEJM Evid · 2022

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Abstract

Mortality rates of infants (younger than 1 year of age) and neonates (younger than 1 month of age) remain unacceptably high in some geographic regions.<sup>1,2</sup> After the first week of life, infection is a significant cause of neonatal and postneonatal mortality.<sup>3,4</sup> Biannual mass azithromycin administration has been shown to reduce all-cause childhood mortality by as much as 25% among infants 1 to 5 months of age in Niger.<sup>5</sup>.