Is Noninferior Not Inferior?

Kadire, Siri; Hardin, Charles C; Takvorian, Katherine S; Sacks, Chana A · NEJM Evid · 2022

review · Level V

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Abstract

Is Noninferior Not Inferior? What is a non-inferiority trial margin? To answer this, ask whether you have ever weighed a tradeoff between the best version of something and an acceptable alternative. Restated, in a choice between two decisions, is one option not inferior to the other? Watch an animated video that explores the basis for non-inferiority trials, the meaning of non-inferiority margins, and the interpretation of a non-inferiority trial's results.