Data and Safety Monitoring Board Monitoring of Clinical Trials for Early Efficacy.

Dodd, Lori E; Proschan, Michael A · NEJM Evid · 2022

review · Level V

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Abstract

DSMB Monitoring of Clinical Trials for Early EfficacyIn this article in the <i>NEJM Evidence</i> DSMB mini-series, Dodd and Proschan review the clinical, ethical, and statistical issues that confront a DSMB when trial data suggest that the treatment under test is highly efficacious. Examples of such trials are reviewed.

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