Early Termination of Clinical Trials for Futility - Considerations for a Data and Safety Monitoring Board.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 38319261.
- Also identified by DOI 10.1056/EVIDctw2100020.
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Abstract
Early Termination of Clinical Trials for FutilityClinical trials may be stopped for futility if there is little or no chance of demonstrating the hoped-for effect. Reasons include evidence of no treatment effect, substantial missing data that would unacceptably undermine trial conclusions, or event rates too low to support meaningful comparisons. This review examines issues faced by DSMBs in such settings.
Medical subject headings
- Medical Futility
- Early Termination of Clinical Trials
- Clinical Trials Data Monitoring Committees