Outpatient Randomized Controlled Trials in the Covid-19 Era and Beyond.

Connors, Jean M; Brooks, Maria M; Sciurba, Frank C; Krishnan, Jerry A; Bledsoe, Joseph R; Castro, Lauren; Eng, Heather; Handberg, Eileen et al. · NEJM Evid · 2022

review · Level V

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Abstract

Outpatient Trials in the Covid-19 Era and BeyondA group of investigators had a meeting at the National Heart, Lung, and Blood Institute in May 2020 to discuss ways to decrease thrombotic complications among symptomatic outpatients with Covid-19. The investigators discuss their approach to three specific challenges: conducting a trial remotely, working through regulatory hurdles, and recruiting a diverse population of participants.

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