How Do I Optimize Heart Failure Medications for Patients with Hypotension or Chronic Kidney Disease?

Gilstrap, Lauren G; Vest, Amanda R · NEJM Evid · 2022

review · Level V

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Abstract

HF Medications for Hypotension or CKDThe cornerstone of treatment for HF with reduced ejection fraction is GDMT; however, safely delivering maximal therapy is often hampered by low blood pressure, labile renal function, or both. Reviewing the physiologic basis of GDMT and exploring each drug's mechanism of action and unique properties can enable careful initiation and titration of therapy, even in patients with hypotension or CKD.

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