Clinical Translation of Cardiovascular Biomarkers - A Long and Uncertain Road.
review · Level V
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- Record sourced from PubMed, PMID 38319843.
- Also identified by DOI 10.1056/EVIDe2200222.
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Abstract
Biomarkers in cardiovascular medicine serve to probe disease mechanisms for research, assist in risk stratification, and - in the best cases - guide precise therapies to appropriate patients. In a classic 2007 article, Morrow and de Lemos<sup>1</sup> proposed three criteria by which to evaluate novel cardiovascular biomarkers for clinical use. First, can the biomarker be measured reproducibly in clinical laboratories? Second, does the biomarker add incremental new information to existing tests? And third, will the measurement of the biomarker assist in the care of patients? The answer to the third question often distinguishes a research tool from a clinical instrument.
Medical subject headings
- Biomarkers
- Cardiovascular Diseases