What Is the Best Oral Therapy for <i>Staph aureus</i> Osteomyelitis?

Schechter, Marcos C; Sax, Paul E; Cortés-Penfield, Nicolás · NEJM Evid · 2022

case_report · Level V

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Abstract

Best Oral Therapy for Staph aureus OsteomyelitisA 50-year-old patient with diabetes mellitus has a plantar ulcer at the base of the first metatarsal. Cortical erosions are noted; bone biopsy culture yields <i>Staphylococcus aureus</i> susceptible to methicillin, ciprofloxacin, clindamycin, doxycycline, trimethoprim/sulfamethoxazole, linezolid, and rifampin. The plan is for 4 weeks of antibiotic treatment. Which antibiotic should be prescribed?

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