Progression/Recurrence-Free Survival 2 in Adjuvant Melanoma.

Augustin, Ryan C; Luke, Jason J · NEJM Evid · 2022

rct · Level I

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Abstract

The long-term outcome of patients with stage III melanoma - that is, melanoma that has spread to nearby lymph nodes, lymphatics, or skin - who have received treatment with immune checkpoint inhibitors is of substantial interest. The article by Eggermont et al.<sup>1</sup> published in this issue of <i>NEJM Evidence</i> reports 5-year outcomes from the stage III melanoma trial, KEYNOTE-054, which compared pembrolizumab (anti-programmed cell death protein 1 [PD-1]) with placebo. The data show durable recurrence-free survival (RFS) and distant metastasis-free survival (DMFS).

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