Questions Remain about Targeted Temperature Management in Cardiac Arrest.

Andrea, Luke; Bangar, Maneesha D; Moskowitz, Ari · NEJM Evid · 2022

review · Level V

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Abstract

For decades, targeted temperature management (TTM) has been a promising intervention for mitigating brain damage after cardiac arrest. Early landmark studies of TTM for out-of-hospital cardiac arrests (OHCAs) with shockable rhythms showed benefits in mortality and neurologic outcome.<sup>1,2</sup> On the basis of these results, TTM was established as standard practice and was given a class I recommendation in the 2010 American Heart Association Guidelines for Cardiopulmonary Resuscitation and Emergency Cardiovascular Care for use in OHCA with initial shockable rhythms, as well as a class IIb recommendation in patients with initial nonshockable rhythms and for in-hospital cardiac arrests (IHCAs).<sup>3</sup>.

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