Bayesian (re)-Analyses of Clinical Trial Data.
rct · Level II
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- Record sourced from PubMed, PMID 38320013.
- Also identified by DOI 10.1056/EVIDe2200297.
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Abstract
The Therapeutic Hypothermia after Pediatric Cardiac Arrest Out-of-Hospital (THAPCA-OH) trial (ClinicalTrials.gov number, NCT00878644) compared therapeutic hypothermia (33°C) with therapeutic normothermia (36.8°C) in 295 children suffering from out-of-hospital cardiac arrest. In the original results, published in the <i>New England Journal of Medicine</i> in 2015, good neurobehavioral outcome and survival at 1 year were higher in the hypothermia group (20% vs. 12% and 38% vs. 29%, respectively); however, these differences did not meet the planned statistical threshold of P<i><</i>0.05.<sup>1</sup>.
Medical subject headings
- Hypothermia, Induced
- Out-of-Hospital Cardiac Arrest
- Cardiopulmonary Resuscitation