The Conundrum of Anticoagulation for Hospitalized Patients with Covid-19.

Merz, Lauren E; Fogerty, Annemarie E · NEJM Evid · 2023

review · Level V

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Abstract

Thrombosis in patients with coronavirus disease 2019 (Covid-19) is driven by complex interactions between immune, complement, fibrinolytic, endothelial, and coagulation systems.<sup>1</sup> In addition to venous thromboembolism (VTE), microthrombi have also been implicated in contributing to end-organ damage, such as acute respiratory distress syndrome and kidney dysfunction, as well as to overall mortality.<sup>1</sup> As available therapies, variants, and vaccines have evolved, so have reported rates of VTE attributable to Covid-19.

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