Epstein-Barr Virus DNA Screening in Asymptomatic People without Known Nasopharyngeal Cancer.

Izumchenko, Evgeny; Vokes, Everett E · NEJM Evid · 2023

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Abstract

Nasopharyngeal carcinoma is an uncommon head and neck malignancy in most parts of the world but is endemic in Southeast Asia and North Africa.<sup>1</sup> Over 130,000 new cases were recorded globally and 80,000 patients succumbed to nasopharyngeal carcinoma in 2020.<sup>2</sup> Owing to relatively mild symptoms during early stages, most patients are diagnosed with clinically advanced disease, and the 5-year overall survival for these patients remains approximately 50%.<sup>3</sup> Hence, early detection when the disease is most treatable may improve clinical outcomes.

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