The Persistence of SARS-CoV-2 and Its Role in Long Covid.

Lineburg, Katie E; Smith, Corey · NEJM Evid · 2023

review · Level V

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Abstract

Postacute sequelae of coronavirus disease 2019 (PASC), more commonly known as long Covid, manifests as ongoing symptoms in various organs of the body more than 4 weeks after the resolution of acute Covid-19.<sup>1</sup> A prevalent symptom of PASC is an ongoing loss of taste, but additional persisting symptoms can include neurologic, gastrointestinal, kidney, lung, or heart dysfunction.<sup>1,2</sup> There are two broad mechanisms that are thought to underpin the ongoing complications associated with PASC: dysregulated production of inflammatory cytokines and the persistence of virus.<sup>3</sup>.

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