Statistics of Rare Events.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 38320520.
- Also identified by DOI 10.1056/EVIDe2300303.
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Abstract
Rare events can sometime arise in clinical development of treatments. For example, CYPIDES was a single-arm study of the CYP11A1 inhibitor ODM-208 to treat metastatic prostate cancer.<sup>1</sup> Preclinical testing of the compound identified elevated thyroid-stimulating hormone (TSH) and bilirubin in rats and dogs. Unusual findings in preclinical testing focus attention and magnify evidence if similar results occur in humans. By analogy, imagine a murder trial in which the only evidence against the defendant arose from a database search of DNA matching the partial profile found at the crime scene. Multiple people could match, so without other evidence, the perpetrator could be any of them.
Medical subject headings
- Hyperthyroidism
- Prostatic Neoplasms