Type 2-polarized memory B cells hold allergen-specific IgE memory.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38324637.
- Also identified by DOI 10.1126/scitranslmed.adi0944.
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Abstract
Allergen-specific immunoglobulin E (IgE) antibodies mediate pathology in diseases such as allergic rhinitis and food allergy. Memory B cells (MBCs) contribute to circulating IgE by regenerating IgE-producing plasma cells upon allergen encounter. Here, we report a population of type 2-polarized MBCs defined as CD23<sup>hi</sup>, IL-4Rα<sup>hi</sup>, and CD32<sup>low</sup> at both the transcriptional and surface protein levels. These MBC2s are enriched in IgG1- and IgG4-expressing cells while constitutively expressing germline transcripts for IgE. Allergen-specific B cells from patients with allergic rhinitis and food allergy were enriched in MBC2s. Furthermore, MBC2s generated allergen-specific IgE during sublingual immunotherapy, thereby identifying these cells as a major reservoir for IgE. The identification of MBC2s provides insights into the maintenance of IgE memory, which is detrimental in allergic diseases but could be beneficial in protection against venoms and helminths.
Medical subject headings
- Rhinitis, Allergic, Seasonal
- Rhinitis, Allergic
- Food Hypersensitivity