Status check: next-generation sequencing for infectious-disease diagnostics.
review · Level V
Where this comes from
- Record sourced from PubMed, PMID 38357923.
- Also identified by DOI 10.1172/JCI178003 and PMC identifier 10866643.
- Licence recorded as CC BY.
- The licence permits redistribution, so the abstract is shown in full and the full text is available from the publisher.
Abstract
Next-generation sequencing (NGS) applications for the diagnostics of infectious diseases has demonstrated great potential with three distinct approaches: whole-genome sequencing (WGS), targeted NGS (tNGS), and metagenomic NGS (mNGS, also known as clinical metagenomics). These approaches provide several advantages over traditional microbiologic methods, though challenges still exist.
Medical subject headings
- High-Throughput Nucleotide Sequencing
- Metagenomics