Unleashing CAR T cells to delay metabolic aging.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38360926.
- Also identified by DOI 10.1038/s43587-024-00576-5 and PMC identifier 11074700.
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Abstract
Amor and colleagues previously developed chimeric antigen receptor (CAR) T cells that can target and eliminate senescent cells. The utility of these senolytic CAR T cells is now expanded to show that they can combat age-related metabolic dysfunction, and that they can be used prophylactically and have effects that persist for months, thus opening the door to the development of long-term senolytic approaches.
Medical subject headings
- Receptors, Chimeric Antigen
- Biochemical Phenomena