In situ single-cell profiling sheds light on IFI27 localisation during SARS-CoV-2 infection.

Tan, Chin Wee; Chen, Jinjin; Liu, Ning; Bhuva, Dharmesh D; Blick, Tony; Monkman, James; Cooper, Caroline; Kharbanda, Malvika et al. · EBioMedicine · 2024

basic_science · Level V

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Abstract

The utilization of single-cell resolved spatial transcriptomics to delineate immune responses during SARS-CoV-2 infection was able to identify M1 macrophages to have elevated expression of IFI27 in areas of infection.

Medical subject headings