Fenton-like Reaction Inspired "·OH Catalyzed" Osteogenic Process for the Treatment of Osteoporosis.
basic_science · Level V
Where this comes from
- Record sourced from PubMed, PMID 38381065.
- Also identified by DOI 10.1002/adhm.202304091.
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Abstract
Inspired by the Fenton-like reaction, this work combines copper peroxide (CP) nanoparticles with black phosphorus (BP) nanosheets to form a hydroxyl radical (·OH)-centered "catalytic" osteogenic system. CP-produced ·OH interacts with BP to rapidly produce a large amount of phosphate ions, thus accelerating self-mineralization and promoting bone formation. In turn, BP not only exerts anti-inflammatory effects, thereby providing a favorable microenvironment for bone formation, but also offsets the potential toxicity of CP induced by reactive oxygen species (ROS). Together with copper ions (Cu<sup>2+</sup>), phosphate ions are also released as a byproduct of this process, which can contribute to the comprehensive promotion of osteogenesis.
Medical subject headings
- Osteoporosis
- Osteogenesis
- Hydroxyl Radical
- Copper
- Phosphorus