Excitotoxicity and ALS: New therapy targets an old mechanism.
basic_science · Level V
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- Record sourced from PubMed, PMID 38382464.
- Also identified by DOI 10.1016/j.xcrm.2024.101423 and PMC identifier 10897583.
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Abstract
Excitotoxicity-induced cell death in motor neurons is a major therapeutic target for amyotrophic lateral sclerosis (ALS). Yan et al.<sup>1</sup> present a novel compound to specifically disrupt extra-synaptic NMDAR complexes, extending the lifespan of the SOD1<sup>G93A</sup> ALS mouse and ameliorating cell death.
Medical subject headings
- Amyotrophic Lateral Sclerosis